Vigilante Bio - Mach BETA 3yr
Today’s Change (Mar 18, 2026)
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About
Rules-based biotech strategy that flips between LABU (3x long) and LABD (3x short) using trend, volatility, and cross-asset cues. QQQ sets risk on/off; Treasuries or UVXY are used in risk-off. A kill switch avoids buying dips in macro selloffs. LABD profits fund rare-disease research.
Goal: profit from biotech up and down moves using LABU (triple-long) or LABD (triple-short).
1) Market check: if QQQ is above its 35-day average we're risk-on; otherwise we sit in TMF (long Treasuries) or UVXY (volatility), with rare LABU bounce buys.
2) In risk-on, we choose LABU vs LABD by biotech trend (XBI), volatility (UVXY) and interest-rate trend. RSI (a short-term "heat" gauge): very high => tilt to LABD.
Kill switch: don't buy dips when biotech drops with the market.
Out-of-sample edge: Sharpe ~16.8 vs S&P ~2.5, drawdown under 1%, Calmar sky-high, and annualized return vastly higher. Superior risk-adjusted growth with stronger downside protection vs the S&P 500.
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Invest in this strategy
OOS Start Date
Jan 2, 2026
Trading Setting
Daily
Type
Stocks
Category
Biotech, long/short, leveraged etfs, trend/momentum, volatility-aware, tactical allocation, risk management
Tickers in this symphonyThis symphony trades 9 assets in total
Ticker
Type
LABD
Direxion Daily S&P Biotech Bear 3X ETF
Stocks
LABU
Direxion Daily S&P Biotech Bull 3X ETF
Stocks
QQQ
Invesco QQQ Trust, Series 1
Stocks
SOXL
Direxion Daily Semiconductor Bull 3X ETF
Stocks
TLT
iShares 20+ Year Treasury Bond ETF
Stocks
TMF
Direxion Daily 20+ Year Treasury Bull 3X ETF
Stocks
TMV
Direxion Daily 20+ Year Treasury Bear 3X ETF
Stocks
UVXY
ProShares Ultra VIX Short-Term Futures ETF
Stocks
XBI
State Street SPDR S&P Biotech ETF
Stocks